What does it mean when someone tells you: "you have cancer"? Initially you're probably consumed with questions like: "how did this happen?" and "will this cancer kill me?". In this unit, we will explore all aspects of the "cancer problem" from the underlying biomedical and environmental causes, through to emerging approaches to cancer diagnosis and treatment. You will integrate medical science knowledge from a diverse range of disciplines and apply this to the prevention, diagnosis and treatment of cancer both at the individual and community level. Together we will explore the epidemiology, aetiology and pathophysiology of cancer. You will be able to define problems and formulate solutions related to the study, prevention and treatment of cancer with consideration throughout for the economic, social and psychological costs of a disease that affects billions. Face-to-face and online learning activities will allow you to work effectively in individual and collaborative contexts. You will acquire the skills to interpret and communicate observations and experimental findings related to the "cancer problem" to diverse audiences. Upon completion, you will have developed the foundations that will allow you to follow a career in cancer research, clinical and diagnostic cancer services and/or the corporate system that supports the health care system.

Biotechnological advances have given rise to an explosion of original and shared public data relevant to human health. These data, including the monitoring of expression levels for thousands of genes and proteins simultaneously, together with multiple databases on biological systems, now promise exciting, ground-breaking discoveries in complex diseases. Critical to these discoveries will be our ability to unravel and extract information from these data. In this unit, you will develop analytical skills required to work with data obtained in the medical and diagnostic sciences. You will explore clinical data using powerful, state of the art methods and tools. Using real data sets, you will be guided in the application of modern data science techniques to interrogate, analyse and represent the data, both graphically and numerically. By analysing your own real data, as well as that from large public resources you will learn and apply the methods needed to find information on the relationship between genes and disease. Leveraging expertise from multiple sources by working in team-based collaborative learning environments, you will develop knowledge and skills that will enable you to play an active role in finding meaningful solutions to difficult problems, creating an important impact on our lives.

Diagnostic sciences have evolved at a rapid pace and provide the cornerstone of our health care system. Effective diagnostic assays enable the identification of people who have, or are at risk of, a disease, and guide their treatment. Research into the pathophysiology of disease underpins the discovery of novel biomarkers and in turn, the development of revolutionary diagnostic assays that make use of state-of-the-art molecular and cellular methods. In this unit you will explore a diverse range of diagnostic tests and gain valuable practical experience in a number of core diagnostic methodologies, many of which are currently used in hospital laboratories. Together we will also cover the regulatory, social, and ethical aspects of the use of biomarkers and diagnostic tests and explore the pathways to their translation into clinical practice. By undertaking this unit, you will develop your understanding of diagnostic assays and biomarkers and acquire the skills needed to embark on a career in diagnostic sciences.

Clinical science is a multidisciplinary science that combines the principles of experimental science with translational medicine. As a clinical scientist, you will have the capacity to interpret test results, isolate causes of disease, and ultimately develop new treatments that will save lives. Clinical Science will provide you with the breadth and depth of knowledge and skills that will give you a broad foundation of knowledge and open up a range of career opportunities in clinical sciences, including medical research, pharmaceutical development and clinical diagnostics. You will learn the language of the clinical world as you develop expertise in literature searching, study design, data interrogation and interpretation, evidence-based decision-making, and current knowledge in medical research. You will explore how discoveries in the medical sciences are translated into clinical practice, and pose your own clinical questions for investigation. You will study important medical conditions from the areas of infectious and genetic diseases and immunity. The capstone experience of your study in Clinical Science will be a short internship in a sector of the clinical sciences of your interest, such as a diagnostic lab, a research lab or a clinical trials centre.

This unit of study provides the fundamental grounding in four basic areas in Pharmacology: (1) principles of drug action (2) pharmacokinetics and drug metabolism (3) experimental design and autonomic pharmacology, and (4) drug design. The delivery of material involves lectures, practicals, computer-aided learning and problem-based workshops. Practical classes provide students with the opportunity of acquiring technical experience and teamwork skills. Problem-based workshops are based on real-life scenarios of drug use in the community. These workshops require students to integrate information obtained in lectures in order to provide solutions to the problems. Online quizzes accompany each module and are to encourage continued learning throughout the semester.

This unit of study examines four important areas of Pharmacology: (1) Principles of drug action in the nervous system; (2) Drug abuse, addiction and analgesia; (3) Drug treatment of allergies and GI disorders; (4) Introduction to drug discovery and development. The delivery of material involves lectures, practicals, computer-aided learning and problem-based workshops. Practical classes provide students with the opportunity of acquiring technical experience and teamwork skills. Problem-based workshops are based on real-life scenarios of drug use in the community. These workshops require students to apply information obtained in lectures and readings in order to 'solve' the problems. Workshop activities will include oral presentations.

This unit of study is designed to introduce students with a basic understanding of pharmacology to the discipline of toxicology. The study of toxicology is central to the assessment of drug safety in drug development and in the explanation of toxicology associated with registered drugs (adverse drug reactions) and drug-drug interactions. These issues as well as the pharmacogenetic basis of adverse reactions will be considered. Environmental toxicology, particularly toxic reactions to environmental agents such as asbestos and pesticides, and target organ toxicology (lung, liver, CNS) are also covered. The diverse world of plants and animal toxins will also be explored. As a final consequence of exposure to many toxicants, the biology and causes of cancer are discussed. As part of the unit students are introduced to basic ideas about the collection and analysis of data from human and animal populations, both in the structured situation of clinical trials, forensic problems and in analysis of epidemiological data.

This unit of study extends on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of the scientific basis of current and novel approaches to pharmacological treatment for major health challenges of the 21st century. Lecture topics, tutorials and laboratory sessions cover drug treatment of arthritis, cardiovascular disorders, cancer, diabetes and protein misfolding disorders. New approaches to the development of next-generation targeted drugs are also introduced. As part of this course all students will extend the practical skills in understanding scientific literature, statistical analysis, critical problem solving and analytical thinking. Each student will conduct a capstone elective project (laboratory or literature-based) in applied pharmacology supervised by academic members of the department.

This unit of study builds on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of neuropharmacology. The neuropharmacology of the major neurotransmitters and their role in neuropsychiatric diseases is explored together with the treatment of conditions such as Alzheimer's disease, movement disorders, stroke, depression, anxiety, epilepsy, pain and schizophrenia. Elective projects relate to current research areas in Pharmacology.

This unit of study offers an introduction to the basic concepts underpinning physiology, excitable cell (nerve and muscle) physiology, as well as the functions of the nervous system (central processing, and sensory and motor systems). It also incorporates cardiovascular and exercise physiology. The practical component involves experiments on humans and isolated tissues, with an emphasis on hypothesis generation and data analysis. Tutorial sessions develop critical thinking, the integrative nature of physiology, and generic skills in scientific writing and presentation. The practicals and tutorials also emphasise group learning and team work.

This unit of study offers a basic introduction to the functions of the remaining body systems: gastrointestinal, respiratory, haematology, endocrine, reproductive and renal. The practical component involves experiments on humans and computer simulations, with an emphasis on hypothesis generation and data analysis. The tutorial sessions develop critical thinking and graduate attributes while demonstrating the integrative nature of physiology. Oral and written communication skills are emphasized, as well as group learning and team work.

This unit provides an introduction the mechanisms that drive neurons and neural circuits throughout the brain and body. The lectures explore how signal intensity is translated into nerve impulse codes and how this information is again translated through synapses to convey and interpret information about the external world, to control the body and to record information for future use (learning and memory). We also consider how sensory and motor information is integrated through neural circuits in the brain and spinal cord. Practical classes introduce some of the different ways in which the workings of the brain are studied. Each student chooses a journal club that focuses on a specific topic in neuroscience. In the weekly sessions, group members read, present and interpret original research papers, developing a deep understanding of the emerging scientific evidence in the topic area. This senior year unit of study will develop skills in critical analysis, interpretation and communication of new evidence.

The aim of this unit is to provide students with advanced knowledge of cellular physiology. There will be a detailed exploration of the signals and pathways cells use to detect and respond to environmental changes and cues. Important signalling systems and homeostatic regulators will be discussed in the context of biological processes and human diseases. Problem-based learning sessions will explore these diseases with student-led teaching. Practical classes will explore physiological techniques for investigating cell signalling and the biophysical properties of cells. Large class tutorials will focus on graduate attribute skills development in the context of reinforcing material discussed in the lectures and practical classes. This unit will develop key attributes that are essential for a science graduate as they move forward in their careers.

The aim of this unit is to provide students with advanced knowledge of whole body physiology. Lectures will provide insight into the mechanisms that regulate homeostasis throughout the whole body with a particular focus not only on the interplay between major organ systems, but also variability amongst individuals. The emphasis in this unit is on recent advances at the frontiers of human physiology. Our current understandings of how we functions will be explored at the molecular, cellular and whole body level. This is detailed fundamental knowledge that is key to understanding the transitions that occur from health to disease. Hands on practical classes will explore the physiology presented in the lectures and tutorial sessions will investigate what 'normal' is in terms of whole body physiology.

The aim of this unit is to provide students with advanced knowledge of whole body physiology. Lectures will provide insight into the mechanisms that regulate normal homeostasis throughout the whole body and how defects in these processes can lead to significant human disease. The emphasis in this unit is on recent advances at the frontiers of human physiology. The processes leading to cancer, cardiovascular and metabolic disease will be explored at the molecular, cellular and whole body level. Problem-based learning will focus on cancer and cardiovascular disease and practical classes will utilise both wet lab and online resources to dissect the processes by which normal physiological processes become aberrant leading to human disease.

This unit of student covers the musculo-skeletal anatomy of the human body with particular emphasis on human evolution and comparisons with apes and fossil hominids. The topics covered include the versatility of the human hand, in manipulation and locomotion, bipedalism, climbing and brachiation in apes, and the change in pelvic anatomy associated with bipedalism and obstetric consequences.

This unit of study covers the principles of cell biology and study of the structure of cells, tissues and organ systems at the light and electron microscopic levels. The focus is on human systems. Modern practical applications of histological techniques and analysis for research are also presented.

Students are introduced to the structure and organisation of the central and peripheral nervous system. The course begins with an exploration into the make-up of the individual cells, followed by an examination of the different regions of the nervous system. A final theme of the course touches on the organisation of sensory, motor and integrative systems, together with aspects of higher-order function such as memory and language. The subject covers general concepts of organisation, structure and function of the brain. Tutorial meetings will provide the opportunity to encounter topics in functional anatomy and histology of the brain using photographs, diagrams, models, animations and problem-solving. Topics in identification of central nervous system structure in typical magnetic resonance images will assist in reinforcing the theory of functional anatomy in a format students are likely to encounter in further study and in real-world situations and readings. This course will be of considerable interest to students studying anatomy and related disciplines, as well as those wishing to pursue further study in Neuroscience at senior levels.

Students are introduced to the structure and organisation of the central and peripheral nervous system. The course begins with an exploration into the make-up of the individual cells, followed by an examination of the different regions of the nervous system. A final theme of the course touches on the organisation of various systems (sensory and motor), together with aspects of higher-order function such as memory and language. In essence, the subject covers general concepts of organisation, structure and function of the brain. The laboratory practical sessions offer students the special privilege to examine human specimens in the Anatomy labs and museum. Tutorial meetings will provide the opportunity to encounter topics in functional anatomy and histology of the brain using photographs, diagrams, models, animations and problem-solving. Topics in identification of central nervous system structure in typical magnetic resonance images will assist in reinforcing the theory of functional anatomy in a format students are likely to encounter in further study and in real-world situations and readings. This course will be of considerable interest to students studying anatomy and related disciplines, as well as those wishing to pursue further study in Neuroscience at senior levels.

Where is your pancreas? What about your pituitary gland? How do we pack nine meters of intestines into our body? ANAT2011 is designed for students who are studying human anatomy for the first time, as well as those who have been introduced to human anatomy in biological sciences. In laboratory classes using human cadavers you will gain fundamental knowledge of the anatomy of the brain and nerves; the anatomy of the cardiovascular, respiratory, endocrine and digestive systems, and musculoskeletal anatomy. The laboratory classes are interwoven with lectures, tutorials and discussion groups, as well as on-line quizzes and self-directed learning modules. The course teaches the language of anatomy, as well as knowledge and practical skills in human anatomy, preparing you for many applied anatomical settings. The hands-on laboratory sessions will require you to work together in teams to engage the content, building your interpersonal skills, and fostering a professional attitude towards learning and scientific endeavour. You will also consider the processes of body donation and the ethical, legal and moral frameworks around which people donate their remains for anatomical learning, teaching and research. This unit contains assumed knowledge for entry into the graduate medical program at the University of Sydney, and is also suitable for graduate programs in dentistry, nursing, physical therapies, forensic sciences.

This unit of study aims to provide students with a detailed understanding of the anatomy of the head and neck regions, with a particular emphasis on the functional anatomy of the cranial nerves. This unit of study covers skull, muscles of facial expression, muscles of jaw and neck, ear, eye, nose, oral cavity and larynx and pharynx as well as peripheral distribution of cranial nerves in the head and neck. The functional components of the cranial nerves and their relationship to the special senses and special motor functions such as facial gesture and speech are also studied. The practical sessions aim to provide students with the ability to recognise the structures studied in human prosections and in medical images especially X Rays and CT scans and to know their main anatomical relationships. Students will also be encouraged to relate their understanding of these structures to current research in anatomy and histology and in related fields such as molecular biology and physiology. The course also aims to provide both theoretical and practical skills which can provide a basis for further studies in fields such as physiotherapy, chiropractic or forensic science or in post graduate medicine or dentistry or in areas of research requiring a knowledge of anatomy.

This unit of study aims to introduce students to the area of forensic osteology, which is the study of human skeletal remains within the legal context. Thus the unit of study aims to help students learn about human morphology and variation through the investigation and identification of human bones. It will also help students gain skills in observation and rigorous record taking and in analysis and interpretation. Production of case reports and practice in acting as 'expert witness' will improve students written and oral skills. An additional objective will be to assist students in learning to deal with legal and ethical issues.

This unit of study aims to provide an understanding of the anatomy of the viscera of the thorax, abdomen and pelvis. Structures covered include the heart and associated great vessels, lungs, mediastinum and the abdominal viscera, the alimentary organs and the genitourinary system. The structure of anterior thoracic and abdominal walls and pelvis along with the nerve supply to the viscera and relevant endocrine structures is also covered. Emphasis is placed on the relationship of structure to function especially with respect to the important functions of breathing, digestion, excretion and reproduction. Students will be encouraged to relate their understanding of these structures to current research in anatomy and histology and in related fields such as molecular biology and physiology. The course also aims to provide both theoretical and practical skills which can provide a basis for further studies in fields such as physiotherapy, chiropractic or forensic science or in post graduate medicine or dentistry or in areas of research requiring a knowledge of anatomy.

The unit provides an opportunity for students to study the topographical and systems anatomy of the upper limb, lower limb and the back regions. Emphasis is placed upon the identification and description of structures and the correlation of structure with function. This includes for the upper limb, its role in manipulation, for the lower limb standing and walking and for the back flexible support and protection. Emphasis is also given to the innervation of the limbs. The unit also aims to develop the general skills of observation, description, drawing, writing and discussion as applying to biological structure.

The aim of this unit is to provide students with advanced knowledge of functional neuroanatomy and systems neuroscience, and an appreciation that neuroscience is a constantly evolving field. There will be a detailed exploration of the anatomical structures and pathways that underlie sensation and perception in each of the sensory modalities. The neural circuits and mechanisms that control somatic and autonomic motor systems, motivated behaviours, emotions, and other higher order functions will be explored in great detail based on current neuroscience literature. Practical classes will allow students to identify and learn the functions of critical anatomical structures in human brain and spinal cord specimens. Reading and interpreting images from functional and structural brain imaging techniques will be incorporated into the neuroanatomy practical classes, and develop an appreciation of how these technologies can be used in neuroscience research. The Neuroscience in the Media seminars will develop neuroscience literature searching skills as well as developing critical thinking and analysis of the accuracy of themedia portrayal of neuroscience research. Building on these skills and working in small groups, students will re-frame and communicate neuroscience evidence through the production of a short video. Students will also learn the skills required to write an unbiased and accurate popular media article based on a recent neuroscience research paper. This unit will develop key attributes that are essential for science graduates as they move forward in their careers.

The aim of this unit is to provide students with advanced knowledge of functional neuroanatomy and systems neuroscience, and an appreciation that neuroscience is a constantly evolving field. There will be a detailed exploration of the anatomical structures and pathways that underlie sensation and perception in each of the sensory modalities. The neural circutis and mechanisms that control somatic and autonomic motor systems, motivated behaviours, emotions, and other higher order functions will be explored in great detail based on current neuroscience literature. Practical classes will allow students to identify and learn the functions of critical anatomical structures in human brain and spinal corde specimens. Reading and interpreting images from functional ans tructural brain imaging techniques will be incorporated intot the neuroanatomy practical classes, and develop an appreciation of how these technologies can be used in neuroscience research. By undertaking the advanced unit students will participate in weekly small group seminars under the guidance of a research-active academic. The seminars will take the form of a Journal Club, a style practiced widely in research laboratories around the world. The aim of the Journal Club is to develop critical thinking and detailed knowledge in a specific area of neuroscience research through group discussions. The Journal Club will also develop the skills required to lead a discussion in a small group setting and construct a neuroscience review article. This unit will develop key attributes that are essential for science graduates as they move forward in their careers.

This second semester unit is designed to introduce students to "cutting edge" issues in the neurosciences. This course is a combination of small lectures on current issues in cellular and developmental neuroscience and a research-based library project. Issues covered in the lecture series will include the role of glial on cerebral blood flow and neural transmission, neurochemistry and psychiatric disorders and the development of central and peripheral nervous systems.

This second semester unit is designed to introduce students to "cutting edge" issues in the neurosciences and to be taken in conjunction with NEUR3003. This course is a combination of small group lectures on current issues in neuroscience, seminar groups and a research-based library project. Seminars will be held on topics including imaging pain, emotions, cortical development and plasticity, colour vision, stroke and hypertension, and long-term regulation of blood pressure.

Our immune system not only protects us from viruses, bacteria, and parasites, it can prevent the growth of tumours. Sometimes our immune system can be the cause of diseases like multiple sclerosis, Type 1 diabetes and rheumatoid arthritis. If you are interested in studying how our immune system works to keep us alive, then Introductory Immunology is for you. This unit of study will provide an overview of the immune system and the essential features of immune responses. You will be treated to a lecture course delivered by cutting edge immunologists that begins with a study of immunology as a basic research science. This includes an introduction to the nature of the cells and molecules involved in the immune response. We build on this foundation by introducing the immunological principles underlying the eradication of infectious diseases, successful vaccination strategies, organ transplantation, combatting autoimmune diseases and treating cancer. The integrated tutorials will build on the lecture material as well as provide you with instructions on how to successfully locate and critically analyse scientific literature. The practical sessions will further illustrate particular concepts introduced in the lecture program and provide you with valuable exposure to a variety of very important immunological techniques.

This study unit builds on the series of lectures that outlined the general properties of the immune system, effector lymphocytes and their functions, delivered in the core courses, IMMU2101 - Introductory Immunology and BMED2404 - Microbes, Infection and Immunity (formerly IMMU2001 and BMED2807). In this unit the molecular and cellular aspects of the immune system are investigated in detail. We emphasise fundamental concepts to provide a scientific basis for studies of the coordinated and regulated immune responses that lead to elimination of infectious organisms. Guest lectures from research scientists eminent in particular branches of immunological research are a special feature of the course. These provide challenging information from the forefront of research that will enable the student to become aware of the many components that come under the broad heading 'Immunology'. Three lectures (1 hour each) will be given each fortnight: 2 lectures in one week and one lecture the following week, for the duration of the course. This unit directly complements the unit 'Immunology in Human Disease IMMU3202' and students are very strongly advised to undertake these study units concurrently.

This study unit builds on the series of lectures that outlined the general properties of the immune system, effector lymphocytes and their functions, delivered in the core courses, IMMU2101 - Introductory Immunology and BMED2404 - Microbes, Infection and Immunity (formerly IMMU2001 and BMED2807). We emphasise fundamental concepts to provide a scientific basis for studies in clinical immunology; dysfunctions of the immune system e.g. autoimmune disease, immunodeficiencies, and allergy, and immunity in terms of host - pathogen interactions. This unit has a strong focus on significant clinical problems in immunology and the scientific background to these problems. The unit includes lectures from research scientists and clinicians covering areas such as allergy, immunodeficiency, autoimmune disease and transplantation. This course provides challenging information from the forefront of clinical immunology and helps the student develop an understanding of immune responses in human health and disease. Three lectures (1 hour each) will be given each fortnight: 2 lectures in one week and one lecture the following week, for the duration of the course. This unit directly complements the unit 'Molecular and Cellular Immunology IMMU3102' and students are very strongly advised to undertake these study units concurrently.

The Pathogenesis of Human Disease 1 unit of study modules will provide a theoretical background to the scientific basis of the pathogenesis of disease. Areas covered in theoretical modules include: tissue responses to exogenous factors, adaptive responses to foreign agents, cardiovascular/pulmonary/gut responses to disease, forensic science, neuropathology and cancer. The aims of the course are: - To give students an overall understanding of the fundamental biological mechanisms governing disease pathogenesis in human beings. - To introduce to students basic concepts of the pathogenesis, natural history and complications of common human diseases. - To demonstrate and exemplify differences between normality and disease. - To explain cellular aspects of certain pathological processes. Together with CPAT3202, the unit of study would be appropriate for those who intend to proceed to Honours research, to postgraduate studies such as Medicine or to careers in biomedical areas such as hospital science. Enquires should be directed to anthea.matsimanis@sydney.edu.au

The Pathogenesis of Human Disease 2 unit of study modules will provide a practical background to the scientific basis of the pathogenesis of disease. Areas covered in practical modules include disease specimen evaluation on a macroscopic and microscopic basis. The aims of the course are: - To enable students to gain an understanding of how different organ systems react to injury and to apply basic concepts of disease processes. - To equip students with skills appropriate for careers in the biomedical sciences and for further training in research or professional degrees. At the end of the course students will: - Have acquired practical skills in the use of a light microscope. - Have an understanding of basic investigative techniques for disease detection in pathology. - Be able to evaluate diseased tissue at the macroscopic and microscopic level. - Have the ability to describe, synthesise and present information on disease pathogenesis. - Transfer problem-solving skills to novel situations related to disease pathogenesis. This unit of study would be appropriate for those who intend to proceed to Honours research, to postgraduate studies such as Medicine or to careers in biomedical areas such as hospital science. Enquiries should be directed to anthea.matsimanis@sydney.edu.au.