Medicinal Chemistry
MEDICINAL CHEMISTRY
Advanced coursework and projects will be available in 2020 for students who complete this major.
Medicinal Chemistry major
A major in Medicinal Chemistry requires 48 credit points from this table including:
(i) 12 credit points of 1000-level core units
(ii) 12 credit points of 2000-level core units
(iii) 12 credit points of 3000-level core units
(iv) 6 credit points of 3000-level selective chemistry units
(v) 6 credit points of 3000-level selective pharmacology units
Medicinal Chemistry minor
A minor in Medicinal Chemistry requires 36 credit points from this table including:
(i) 12 credit points 1000-level core units
(ii) 12 credit points of 2000-level core units
(iii) 12 credit points of 3000-level core units
Units of study
The units of study are listed below.
1000-level units of study
Core
CHEM1011 Fundamentals of Chemistry 1A
Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1 Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1111 or CHEM1911 or CHEM1991 Assumed knowledge: There is no assumed knowledge of chemistry for this unit of study but students who have not completed HSC Chemistry (or equivalent) are strongly advised to take the Chemistry Bridging Course (offered in February). Assessment: quizzes, attendance, laboratory log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Students who have not completed HSC Chemistry (or equivalent) are strongly advised to take the Chemistry Bridging Course (offered in February, and online year-round, see http://sydney.edu.au/science/chemistry/studying-chemistry/bridging-course.shtml).
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in the life, medical and physical sciences, engineering, and industrial processes. This unit of study will equip you with the fundamental knowledge and skills in chemistry for broad application. You will learn about atomic theory, structure and bonding, equilibrium, processes occurring in solutions, and the functional groups of molecules. You will develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions about the chemical nature and processes occurring around you. Through inquiry, observation and measurement, you will better understand natural and physical world and will be able to apply this understanding to real-world problems and solutions. This unit of study is directed toward students whose chemical background is weak (or non-existent). Compared to the mainstream Chemistry 1A, the theory component of this unit begins with more fundamental concepts, and does not cover, or goes into less detail about some topics. Progression to intermediate chemistry from this unit and Fundamentals of Chemistry 1B requires completion of an online supplementary course.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1111 Chemistry 1A
Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1,Semester 2,Summer Main Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1011 or CHEM1911 or CHEM1991 Assumed knowledge: Students who have not completed HSC Chemistry (or equivalent) and HSC Mathematics (or equivalent) are strongly advised to take the Chemistry and Mathematics Bridging Courses (offered in February) Assessment: quizzes, attendance, laboratory log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Students who have not completed secondary school chemistry are strongly advised to instead complete Fundamentals of Chemistry 1A in the first semester of the calendar year (unless you require 12 credit points of Chemistry and are commencing in semester 2). You should also take the Chemistry Bridging Course in advance (offered in February, and online year-round http://sydney.edu.au/science/chemistry/studying-chemistry/bridging-course.shtml).
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in the life, medical and physical sciences, engineering, and industrial processes. This unit of study will further develop your knowledge and skills in chemistry for application to life and medical sciences, engineering, and further study in chemistry. You will learn about nuclear and radiation chemistry, wave theory, atomic orbitals, spectroscopy, bonding, enthalpy and entropy, equilibrium, processes occurring in solutions, and the functional groups in carbon chemistry. You will develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions like how do dyes work, how do we desalinate water, how do we measure the acid content in foods, how do we get the blue in a blueprint, and how do we extract natural products from plants? Through inquiry, observation and measurement, you will understand the 'why' and the 'how' of the natural and physical world and will be able to apply this understanding to real-world problems and solutions. This unit of study is directed toward students with a satisfactory prior knowledge of the HSC chemistry course.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1911 Chemistry 1A (Advanced)
Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1 Classes: 3x1-hr lectures and 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1011 or CHEM1111 or CHEM1991 Assumed knowledge: 80 or above in HSC Chemistry or equivalent Assessment: quizzes, attendance, laboratory log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in sciences, engineering, and industrial processes. This unit of study will further develop your knowledge and skills in chemistry for broad application, including further study in chemistry. You will learn about nuclear and radiation chemistry, wave theory, atomic orbitals, spectroscopy, bonding, enthalpy and entropy, equilibrium, processes occurring in solutions, and the functional groups of molecules. You will develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions about the chemical nature and processes occurring around you. Through inquiry, observation and measurement, you will better understand natural and physical world and will be able to apply this understanding to real-world problems and solutions. This unit of study is directed toward students with a good secondary performance both overall and in chemistry or science. Students in this category are expected to do this unit rather than Chemistry 1A. Compared to the mainstream Chemistry 1A, the theory component of this unit provides a higher level of academic rigour and makes broader connections between topics.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1991 Chemistry 1A (Special Studies Program)
Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1 Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3hr practical per week for 12 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1011 or CHEM1111 or CHEM1911 Assumed knowledge: 90 or above in HSC Chemistry or equivalent Assessment: quizzes, attendance, presentations, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in the life, medical and physical sciences, engineering, and industrial processes. This unit of study will further develop your knowledge and skills in chemistry for application to life and medical sciences, engineering, and further study in chemistry. You will learn about nuclear and radiation chemistry, wave theory, atomic orbitals, spectroscopy, bonding, enthalpy and entropy, equilibrium, processes occurring in solutions, and the functional groups in carbon chemistry. You will develop experimental design, conduct and analysis skills in chemistry in small group projects. The laboratory program is designed to extend students who already have chemistry laboratory experience, and particularly caters for students who already show a passion and enthusiasm for research chemistry, as well as aptitude as demonstrated by high school chemistry results. Entry to Chemistry 1A (Special Studies Program) is restricted to a small number of students with an excellent school record in Chemistry, and applications must be made to the School of Chemistry. The practical work syllabus for Chemistry 1A (Special Studies Program) is very different from that for Chemistry 1A and Chemistry 1A (Advanced) and consists of special project-based laboratory exercises. All other unit of study details are the same as those for Chemistry 1A (Advanced).
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1012 Fundamentals of Chemistry 1B
Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 2 Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prerequisites: CHEM1XX1 Prohibitions: CHEM1002 or CHEM1102 or CHEM1902 or CHEM1904 or CHEM1108 or CHEM1112 or CHEM1912 or CHEM1992 Assessment: quizzes, assignments, laboratory attendance and log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Chemistry transforms the way we live. It provides the basis for understanding biological, geological and atmospheric processes, how medicines work, the properties of materials and substances, how beer is brewed, and for obtaining forensic evidence. This unit of study builds upon your prior knowledge of chemistry to further develop your knowledge and skills in chemistry for broad application. You will learn about organic chemistry reactions, structural determination, nitrogen chemistry, industrial processes, kinetics, electrochemistry, thermochemistry, phase behaviour, solubility equilibrium and chemistry of metals. You will further develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions about the chemical nature and processes occurring around you. Through enquiry, observation and measurement, you will better understand natural and physical world and will be able to apply this understanding to real-world problems and solutions. Fundamentals of Chemistry 1B is built on a satisfactory prior knowledge of Fundamentals of Chemistry 1A. Compared to the mainstream Chemistry 1B, the theory component of this unit begins with more fundamental concepts, and does not cover, or goes into less detail about some topics. Progression to intermediate chemistry from this unit requires completion of an online supplementary course.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1112 Chemistry 1B
Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1,Semester 2 Classes: 1x3-hr lecture; 1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prerequisites: CHEM1111 or CHEM1911 or CHEM1101 or CHEM1901 or (75 or above in CHEM1011 or CHEM1001) Prohibitions: CHEM1002 or CHEM1102 or CHEM1902 or CHEM1904 or CHEM1108 or CHEM1012 or CHEM1912 or CHEM1992 Assessment: quizzes, assignments, laboratory attendance and log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Chemistry transforms the way we live. It provides the basis for understanding biological, geological and atmospheric processes, how medicines work, the properties of materials and substances, how beer is brewed, and for obtaining forensic evidence. This unit of study builds upon your prior knowledge of chemistry to further develop your knowledge and skills in chemistry for application to life and medical sciences, engineering, industrial processing, and further study in chemistry. You will learn about organic chemistry reactions, structural determination, nitrogen chemistry, industrial processes, kinetics, electrochemistry, thermochemistry, phase behaviours, solubility equilibrium and chemistry of metals. You will further develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions like how do we develop lotions that don't burn us, how do we measure UV absorption by sunscreens, how can we measure and alter soil pH, how are sticky things made, and how do we determine the concentration of vitamin C in juice? Through enquiry, observation and measurement, you will understand the 'why' and the 'how' of the natural and physical world and will be able to apply this understanding to real-world problems and solutions. Chemistry 1B is built on a satisfactory prior knowledge of Chemistry 1A.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1912 Chemistry 1B (Advanced)
Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 2 Classes: 3x1-hr lectures and 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prerequisites: CHEM1911 or CHEM1991 or CHEM1901 or CHEM1903 or (75 or above in CHEM1111 or CHEM1101) or (90 or above in HSC Chemistry or equivalent) Prohibitions: CHEM1002 or CHEM1102 or CHEM1902 or CHEM1904 or CHEM1108 or CHEM1012 or CHEM1112 or CHEM1992 Assessment: quizzes, assignments, laboratory attendance and log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Students who commence in semester 2 are strongly advised that you would be better served by taking the mainstream level units in sequence, Chemistry 1A before Chemistry 1B, rather than the Advanced units in the opposite order.
Chemistry transforms the way we live. It provides the basis for understanding biological, geological and atmospheric processes, how medicines work, the properties of materials and substances, how beer is brewed, and for obtaining forensic evidence. This unit of study builds upon your prior knowledge of chemistry to further develop your knowledge and skills in chemistry for broad application, including further study in chemistry. You will learn about organic chemistry reactions, structural determination, nitrogen chemistry, industrial processes, kinetics, electrochemistry, thermochemistry, phase behaviour, solubility equilibrium and chemistry of metals. You will further develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions about the chemical nature and processes occurring around you. Through enquiry, observation and measurement, you will better understand natural and physical world and will be able to apply this understanding to real-world problems and solutions. Chemistry 1B (Advanced) is built on a satisfactory prior knowledge of Chemistry 1A (Advanced). Compared to the mainstream Chemistry 1B, the theory component of this unit provides a higher level of academic rigour and makes broader connections between topics.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1992 Chemistry 1B (Special Studies Program)
Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 2 Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3-hr practical per week for 12 weeks Prerequisites: 75 or above in CHEM1991 or CHEM1903 or (90 or above in HSC Chemistry or equivalent) Prohibitions: CHEM1002 or CHEM1102 or CHEM1902 or CHEM1904 or CHEM1108 or CHEM1012 or CHEM1112 or CHEM1912 Assessment: quizzes, assignment, skills-based assessment, final exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Entry is by invitation. This unit of study is deemed to be an Advanced unit of study. Students who commence in semester 2 are strongly advised that you would be better served by taking the mainstream level units in sequence, Chemistry 1A before Chemistry 1B, rather than the Special Studies Program units in the opposite order.
Chemistry transforms the way we live. It provides the basis for understanding biological, geological and atmospheric processes, how food and medicines work, the properties of materials and substances. This unit of study builds upon your prior knowledge of chemistry to further develop your knowledge and skills in chemistry for application to life and medical sciences, engineering, industrial processing, and further study in chemistry. You will learn about organic chemistry reactions, structural determination, nitrogen chemistry, industrial processes, kinetics, electrochemistry, thermochemistry, phase behaviour, solubility equilibrium and chemistry of metals. You will develop experimental design, conduct and analysis skills in chemistry in small group projects. The laboratory program is designed to extend students, and particularly caters for students who already show a passion and enthusiasm for research chemistry, as well as a demonstrated aptitude. Chemistry 1B (Special Studies Program) is restricted to students who have gained a Distinction in Chemistry 1A (Special Studies Program) or by invitation. The practical work syllabus for Chemistry 1B (Special Studies Program) is very different from that for Chemistry 1B and Chemistry 1B (Advanced) and consists of special project-based laboratory exercises. All other unit of study details are the same as those for Chemistry 1B (Advanced).
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
2000-level units of study
Core
CHEM2401 Molecular Reactivity and Spectroscopy
Credit points: 6 Teacher/Coordinator: A/Prof Siegbert Schmid Session: Semester 1 Classes: Three 1-hour lectures per week, seven 1-hour tutorials per semester, eight 4-hour practicals per semester Prerequisites: (CHEM1XX1 or CHEM1903) and (CHEM1XX2 or CHEM1904) Prohibitions: CHEM2001 or CHEM2101 or CHEM2301 or CHEM2311 or CHEM2502 or CHEM2901 or CHEM2903 or CHEM2911 or CHEM2915 Assumed knowledge: 6cp MATH1XXX Assessment: Quizzes, lab reports and final examination (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
Note: This is a required chemistry unit of study for students intending to major in chemistry.
This is one of the two core units of study for students considering majoring in chemistry, and for students of other disciplines who wish to acquire a good general background in chemistry. The unit considers fundamental questions of molecular structure, chemical reactivity, and molecular spectroscopy: What are chemical reactions and what makes them happen? How can we follow and understand them? How can we exploit them to make useful molecules? This course includes the organic and medicinal chemistry of aromatic and carbonyl compounds, organic reaction mechanisms, molecular spectroscopy, quantum chemistry, and molecular orbital theory.
Textbooks
See http://sydney.edu.au/science/chemistry/studying-chemistry/undergraduate/intermediate-chemistry.shtml
CHEM2911 Molecular Reactivity and Spectroscopy Adv
Credit points: 6 Teacher/Coordinator: A/Prof Siegbert Schmid Session: Semester 1 Classes: Three 1-hour lectures per week, seven 1-hour tutorials per semester and eight 4-hour practicals per semester Prerequisites: (A mark of 65 or above in CHEM1111 or CHEM1101 or CHEM1911 or CHEM1901 or CHEM1991 or CHEM1903) and (a mark of 65 or above in CHEM1112 or CHEM1102 or CHEM1912 or CHEM1902 or CHEM1992 or CHEM1904) Prohibitions: CHEM2001 or CHEM2101 or CHEM2301 or CHEM2311 or CHEM2312 or CHEM2401 or CHEM2502 or CHEM2901 or CHEM2903 or CHEM2915 Assumed knowledge: 6cp MATH1XXX Assessment: Quizzes, lab reports and final examination (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
The syllabus for this unit is the same as that of CHEM2401 together with special Advanced material presented in the practical program. The lectures cover fundamental consideration of molecular electronic structure and its role in molecular reactivity and spectroscopy and include applications of spectroscopy, the organic chemistry of aromatic systems, molecular orbital theory and quantum chemistry. For more details of the lecture syllabus, please read the entry for CHEM2401.
Textbooks
See http://sydney.edu.au/science/chemistry/studying-chemistry/undergraduate/intermediate-chemistry.shtml
CHEM2915 Molecular Reactivity and Spectroscopy SSP
Credit points: 6 Teacher/Coordinator: A/Prof Siegbert Schmid Session: Semester 1 Classes: Three 1-hour lectures per week, twelve 1-hour SSP seminars per semester, eight 4-hour practicals per semester Prerequisites: (A mark of 75 or above in CHEM1111 or CHEM1101 or CHEM1911 or CHEM1901 or CHEM1991 or CHEM1903) and (a mark of 75 or above in CHEM1112 or CHEM1102 or CHEM1912 or CHEM1902 or CHEM1992 or CHEM1904) Prohibitions: CHEM2001 or CHEM2101 or CHEM2301 or CHEM2311 or CHEM2312 or CHEM2401 or CHEM2502 or CHEM2901 or CHEM2903 or CHEM2911 Assumed knowledge: 6cp MATH1XXX Assessment: Quizzes, assignments, lab reports and final examination (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Note: The number of places in this unit of study is strictly limited and entry is by invitation only. Enrolment is conditional upon available places.
The lectures for this unit comprise the lectures for CHEM2401 and the Advanced practical program together with additional SSP seminars.
Textbooks
See http://sydney.edu.au/science/chemistry/studying-chemistry/undergraduate/intermediate-chemistry.shtml
PCOL2011 Pharmacology Fundamentals
Credit points: 6 Teacher/Coordinator: Dr Hilary Lloyd Session: Semester 1 Classes: Lectures (2 x1 hr per week); wet and dry labs (5 x4 hrs), data anaylsis tutorials (2 x 2 hrs); workshops (6 x 2 hrs) Prerequisites: 6cp from CHEM1XXX Prohibitions: PCOL2555 orBMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808 Assumed knowledge: BIOL1XXX or MBLG1XX1 Assessment: In-semester (40%), which consists of 4 x on-line quizzes, 2 x lab reports, 3 x research topics, 1 x oral presentation, end-of-semester examination (60%), which consists of multiple choice and short answer questions Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study provides the fundamental grounding in four basic areas in Pharmacology: (1) principles of drug action (2) pharmacokinetics and drug metabolism (3) experimental design and autonomic pharmacology, and (4) drug design. The delivery of material involves lectures, practicals, computer-aided learning and problem-based workshops. Practical classes provide students with the opportunity of acquiring technical experience and teamwork skills. Problem-based workshops are based on real-life scenarios of drug use in the community. These workshops require students to integrate information obtained in lectures in order to provide solutions to the problems. Online quizzes accompany each module and are to encourage continued learning throughout the semester.
Textbooks
Rang and Dale's Pharmacology, 8th Edition. H. P. Rang, J. M. Ritter, R. J. Flower, and G. Henderson, (Elsevier 2016 ). Medical Pharmacology at a Glance, 7th edn M.J. Neal: (Blackwell Scientific Publications, 2012).
3000-level units of study
Core
MCHM3X01 and MCHM3X02 to be developed for offering in 2019.
Chemistry units
CHEM3110 Biomolecules: Properties and Reactions
Credit points: 6 Session: Semester 1 Classes: Two 1-hour lectures and two 4-hour practicals per week for half of semester Prerequisites: (CHEM2401 or CHEM2911 or CHEM2915) and (CHEM2402 or CHEM2912 or CHEM2916) Prohibitions: CHEM3910 Assessment: Assignment, prac reports and oral, final examination (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
DNA, proteins and carbohydrates represent three classes of essential biomolecules present in all biological systems. This unit will cover the structure, reactivity and properties of biomolecules and the building blocks from which these molecules are assembled. Interactions between biomolecules and metalions, small molecules and other biomolecules will be covered and the chemical tools for studying biomolecules highlighted. The design and synthesis of small molecules which mimic the functions of biomolecules will also be illustrated.
Textbooks
See http://sydney.edu.au/science/chemistry/studying-chemistry/undergraduate/senior-chemistry.shtml
CHEM3910 Biomolecules: Properties and Reactions Adv
Credit points: 6 Session: Semester 1 Classes: Two 1-hour lectures per week, one 1-hour seminar per week, and two 4-hour practicals per week for half of semester. Prerequisites: WAM of 65 or greater and (Credit or better in (CHEM2401 or CHEM2911 or CHEM2915)) and (Credit or better in (CHEM2402 or CHEM2912 or CHEM2916)) Prohibitions: CHEM3110 Assessment: Assignments, prac reports and oral, final examination (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
DNA, proteins and carbohydrates represent three classes of essential biomolecules present in all biological systems. This unit will cover the structure, reactivity and properties of biomolecules and the building blocks from which these molecules are assembled. Interactions between biomolecules and metal ions, small molecules and other biomolecules will be covered and the chemical tools for studying biomolecules highlighted. The design and synthesis of small molecules which mimic the functions of biomolecules will also be illustrated. CHEM3910 students attend the same lectures as CHEM3110 students but attend an additional advanced seminar series comprising one lecture a week for 12 weeks.
Textbooks
See http://sydney.edu.au/science/chemistry/studying-chemistry/undergraduate/senior-chemistry.shtml
CHEM3115 Synthetic Medicinal Chemistry
Credit points: 6 Session: Semester 2 Classes: Two 1-hour lectures per week and two 4-hour practicals per week for half of semester. Prerequisites: (CHEM2401 or CHEM2911 or CHEM2915) and (CHEM2402 or CHEM2912 or CHEM2916) Prohibitions: CHEM3915 Assessment: Assignment, prac reports and oral, final examination (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
The development of new pharmaceuticals fundamentally relies on the ability to design and synthesize new compounds. Synthesis is an enabling discipline for medicinal chemistry - without it, the development of new drugs cannot progress from design to implementation, and ultimately to a cure. This unit will tackle important factors in drug design, and will highlight the current arsenal of methods used in the discovery of new drugs, including rational drug design, high throughput screening and combinatorial chemistry. We will develop a logical approach to planning a synthesis of a particular target structure. The synthesis and chemistry of heterocycles, which comprise some 40% of all known organic compounds and are particularly common in pharmaceuticals, will be outlined. Examples will include important ring systems present in biological systems, such as pyrimidines and purines (DNA and RNA), imidazole and thiazole (amino acids and vitamins) and porphyrins (natural colouring substances and oxygen carrying component of blood). Throughout the course, the utility of synthesis in medicinal chemistry will be illustrated with case studies such as anti-influenza (Relenza), anaesthetic (benzocaine), anti-inflammatory (Vioxx), antihypertensive (pinacidil) and cholesterol-lowering (Lovastatin) drugs.
Textbooks
See http://sydney.edu.au/science/chemistry/studying-chemistry/undergraduate/senior-chemistry.shtml
CHEM3915 Synthetic Medicinal Chemistry (Adv)
Credit points: 6 Session: Semester 2 Classes: Two 1-hour lectures per week, one 1-hour seminar per week, and two 4-hour practicals per week for half of semester. Prerequisites: WAM of 65 or greater and (Credit or better in (CHEM2401 or CHEM2911 or CHEM2915)) and (Credit or better in (CHEM2402 or CHEM2912 or CHEM2916)) Prohibitions: CHEM3115 Assessment: Assignments, prac reports and oral, final examination (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
The development of new pharmaceuticals fundamentally relies on the ability to design and synthesize new compounds. Synthesis is an enabling discipline for medicinal chemistry - without it, the development of new drugs cannot progress from design to implementation, and ultimately to a cure. This unit will tackle important factors in drug design, and will highlight the current arsenal of methods used in the discovery of new drugs, including rational drug design, high throughput screening and combinatorial chemistry. We will develop a logical approach to planning a synthesis of a particular target structure. The synthesis and chemistry of heterocycles, which comprise some 40% of all known organic compounds and are particularly common in pharmaceuticals, will be outlined. Examples will include important ring systems present in biological systems, such as pyrimidines and purines (DNA and RNA), imidazole and thiazole (amino acids and vitamins) and porphyrins (natural colouring substances and oxygen carrying component of blood). Throughout the course, the utility of synthesis in medicinal chemistry will be illustrated with case studies such as anti-influenza (Relenza), anaesthetic (benzocaine), anti-inflammatory (Vioxx), antihypertensive (pinacidil) and cholesterol-lowering (Lovastatin) drugs. CHEM3915 students attend the same lectures as CHEM3115 students, but attend an additional advanced seminar series comprising one lecture a week for 12 weeks.
Textbooks
See http://sydney.edu.au/science/chemistry/studying-chemistry/undergraduate/senior-chemistry.shtml
Pharmacology units
PCOL3011 Toxicology
Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 1 Classes: Two 1 hour lectures per week and one 3 hour tutorial/practical every 2 weeks and two practical sessions each 3 hours in length. Prerequisites: PCOL2011 or (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3911 Assessment: One 2 hour exam, tutorial presentations, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the discipline of toxicology. The study of toxicology is central to the assessment of drug safety in drug development and in the explanation of toxicology associated with registered drugs (adverse drug reactions) and drug-drug interactions. These issues as well as the pharmacogenetic basis of adverse reactions will be considered. Environmental toxicology, particularly toxic reactions to environmental agents such as asbestos and pesticides, and target organ toxicology (lung, liver, CNS) are also covered. The diverse world of plants and animal toxins will also be explored. As a final consequence of exposure to many toxicants, the biology and causes of cancer are discussed. As part of the unit students are introduced to basic ideas about the collection and analysis of data from human and animal populations, both in the structured situation of clinical trials, forensic problems and in analysis of epidemiological data.
Textbooks
Klaasen, Curtis D. Casarett and Doull's Essentials of Toxicology 2 ed. McGraw Hill. 2010, or, by the same authors: Toxicology: The Basic Science of Poisons. 7 ed. McGraw Hill. 2008.
PCOL3911 Toxicology (Advanced)
Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 1 Classes: Two 1 hour lectures per week and one 3 hour tutorial/practical every second week. and two practical sessions each 3 hours in length Prerequisites: A mark of 70 or above in [PCOL2011 or (BMED2401 and an additional 12 credit points of BMED240X)] Prohibitions: PCOL3011 Assessment: One 2 hour exam, tutorial presentations, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3011. Students will be set special advanced assignments and additional practical data management activities related to the material covered in lectures and practical work. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Klaasen, Curtis D. Casarett and Doull's Essentials of Toxicology 3rd ed. McGraw Hill. 2015.. or, by the same authors: Toxicology: The Basic Science of Poisons. 8th ed. McGraw Hill. 2013.
PCOL3012 Drug Design and Development
Credit points: 6 Teacher/Coordinator: Dr Brent McParland Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: [PCOL2011 or (BMED2401 and an additional 12 credit points of BMED240X)] or 12 credit points of BCMB2XXX Prohibitions: PCOL3912 Assessment: One 2 hour exam, class and online quizzes, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the field of medicinal chemistry associated with drug design and development. The course covers the fundamental aspects of drug discovery and development with reference to the essentials of chemistry and illustrates drug development with examples that include neuraminidase inhibitors and angiotensin converting enzyme inhibitors. The role of computers in drug design is emphasised by classwork and assignments on molecular modelling and structure-activity relationships. The course also extends to a section on the design of diverse pharmacological agents which include compounds for imaging by positron emission tomography (PET), and kinase inhibitors.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.
PCOL3912 Drug Design and Development (Advanced)
Credit points: 6 Teacher/Coordinator: Dr Brent McParland Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: A mark of 70 or above in [PCOL2011 or (BMED2401 and an additional 12 credit points from BMED240X)] or a mark of 70 or above in 12 credit points of BCMB2XXX Prohibitions: PCOL3012 Assessment: One 2 hour exam, in class and online quizzes, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3012. Students will be set special advanced assignments related to the material covered in core areas. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.